Prothena to Present Data from Two of its Alzheimer’s Disease Programs at the Alzheimer’s Association International Conference 2021
PRX0012: Next-generation, high-potency Aβ antibody for Alzheimer’s disease with best-in-class potential
PRX012 is a next-generation, high-potency monoclonal antibody designed to deliver best-in-class efficacy, safety and patient experience for the treatment of AD. PRX012 binds to the N-terminus of Aβ, a key component of the plaques associated with AD. The PRX012 Investigational New Drug Application (IND) is expected in 1Q 2022. Data to be presented at AAIC will describe the ability of PRX012 to mediate microglial phagocytic clearance of both unmodified Aβ and pyroglutamate-modified AβpE3-42, in plaques of human AD brain tissue ex vivo.
- Poster # 57773, available to view starting
Monday July 26, 2021
- Presenting Author:
Wagner Zago, PhD, Chief Scientific Officer
Dual Aβ-tau vaccine for Alzheimer’s disease
Prothena’s multi-epitope vaccine, is a single agent designed to prevent the two key processes associated with AD: formation of Aβ plaques and intraneuronal tau tangles. Both Aβ and tau are considered main factors underlying the disease development and progression of AD. While the majority of vaccines and passive immunotherapies currently under development target one of these components, Prothena’s vaccine was designed to target both Aβ and tau simultaneously. Preclinical data to be presented at AAIC will describe the generation of appropriate antibody quantities, phagocytosis of Aβ, and blockade of tau binding to heparan-sulfate analog, a surrogate endpoint for neuronal uptake of tau by various vaccine constructs.
- Poster # 52980, available to view starting
Monday July 26, 2021
- Presenting Author: Robin Barbour, Sr. Director, Antibody and
About Alzheimer’s Disease
Alzheimer’s disease is the most common form of dementia causing increasingly serious symptoms, including confusion, disorientation, mood and behavioral changes, difficulty speaking, swallowing and walking. Between 2000-2018, Alzheimer’s as a cause of death increased by 146%. More than 5.8 million Americans are living with Alzheimer’s disease, making it the most common neurodegenerative disorder. There is an urgent need for therapies that slow the progression and ultimately prevent Alzheimer’s disease to address this global healthcare crisis. Prothena’s Alzheimer’s disease portfolio spans next generation antibody immunotherapy, small molecule and vaccine approaches, geared toward building upon first generation treatments to advance the treatment paradigm.
This press release contains forward-looking statements. These statements relate to, among other things, the treatment potentials, designs, and proposed mechanisms of action of PRX012 and our dual Aβ-tau vaccine; and plans for the future clinical studies of PRX012. These statements are based on estimates, projections, and assumptions that may prove not to be accurate, and actual results could differ materially from those anticipated due to known and unknown risks, uncertainties, and other factors, including but not limited to those described in the “Risk Factors” section of our Quarterly Report on form 10-Q filed pursuant to Rule 424(b)5 with the
Source: Prothena Corporation plc